AI-assisted population-PK analysis — run history
Demonstrator for IncreaseNET Task 7.7 · synthetic data only · generated 2026-10-08T14:34:27Z · tool 0.1.0
Run tree
| Run | Type | Spec (methodology) | Status | OFV | Flags (|Δ| > 20%) | Script hash |
|---|---|---|---|---|---|---|
| R-20261008-141821-7241 | primary | 2-cmt · combined · IIV CL/V2/KA · FOCEi · BLQ M1 | completed | 4372.9333 | — | 41f519daf7a1 |
| └─ R-20261008-141836-2b90 | sensitivity | 2-cmt · combined · IIV CL/V2/KA · FOCEi · BLQ M3 | completed | 4397.2982 | — | fdffd00a137b |
| └─ R-20261008-141852-6712 | primaryreplay | 2-cmt · combined · IIV CL/V2/KA · FOCEi · BLQ M1 | completed | 4372.9333 | — | 41f519daf7a1 |
Side-by-side comparison
| Parameter | Applicant | 141821-7241 primary BLQ M1 | 141836-2b90 sensitivity BLQ M3 | 141852-6712 primary · replay BLQ M1 |
|---|---|---|---|---|
| CL/F (L/h) | 4.2 | 4.09 -2.6% | 4.14 -1.4% | 4.09 -2.6% |
| V2/F (L) | 35 | 35.5 +1.3% | 35.2 +0.6% | 35.5 +1.3% |
| V3/F (L) | 120 | 117 -2.1% | 115 -4.4% | 117 -2.1% |
| Q/F (L/h) | 8.1 | 7.94 -1.9% | 7.97 -1.6% | 7.94 -1.9% |
| KA (1/h) | 1.1 | 1.14 +3.6% | 1.13 +3.1% | 1.14 +3.6% |
| IIV CL (CV%) | 30 | 27 -10.0% | 27.4 -8.8% | 27 -10.0% |
| OFV | 4372.9333 | 4397.2982 | 4372.9333 | |
| Observations used | 413 | 420 | 413 | |
| Censored (M3) | 0 | 7 | 0 | |
| Converged | yes | yes | yes |
Cells show the independent estimate and its relative difference to the applicant's value; highlighted values exceed the tolerance.
Requests rejected or not executed
| Time | Request (pseudonymised) | Outcome | Reasons |
|---|---|---|---|
| 2026-10-08T14:18:52Z | Add a time-varying covariate on CL | out of scope – expert review | unsupported request: time-varying covariate on CL |
Determinism checks
| Time | Check | Result |
|---|---|---|
| 2026-10-08T14:18:52Z | Re-render script of R-20261008-141821-7241 from stored spec | identical script hash 41f519daf7a1adac |
| 2026-10-08T14:19:07Z | Re-run R-20261008-141821-7241 → R-20261008-141852-6712 | max relative difference 0 (tolerance 1e-06), OFV 4372.933334 vs 4372.933334 |
Audit log (latest events)
23 events
| Time | Event | Details |
|---|---|---|
| 2026-10-08T14:19:07Z | determinism_replay | |
| 2026-10-08T14:19:07Z | run_completed | R-20261008-141852-6712 completed |
| 2026-10-08T14:18:52Z | qc_completed | R-20261008-141852-6712 |
| 2026-10-08T14:18:52Z | run_started | R-20261008-141852-6712 |
| 2026-10-08T14:18:52Z | determinism_rerender | R-20261008-141821-7241 |
| 2026-10-08T14:18:52Z | request_rejected | |
| 2026-10-08T14:18:52Z | request_interpreted | J-6478513f8d ok |
| 2026-10-08T14:18:52Z | request_received | |
| 2026-10-08T14:18:52Z | run_completed | R-20261008-141836-2b90 completed |
| 2026-10-08T14:18:36Z | qc_completed | R-20261008-141836-2b90 |
| 2026-10-08T14:18:36Z | run_started | R-20261008-141836-2b90 |
| 2026-10-08T14:18:36Z | spec_confirmed | |
| 2026-10-08T14:18:36Z | spec_proposed | |
| 2026-10-08T14:18:36Z | request_interpreted | J-8c5a9b9abc ok |
| 2026-10-08T14:18:36Z | request_received | |
| 2026-10-08T14:18:36Z | run_completed | R-20261008-141821-7241 completed |
| 2026-10-08T14:18:21Z | qc_completed | R-20261008-141821-7241 |
| 2026-10-08T14:18:21Z | run_started | R-20261008-141821-7241 |
| 2026-10-08T14:18:21Z | spec_confirmed | |
| 2026-10-08T14:18:21Z | spec_proposed | |
| 2026-10-08T14:18:21Z | clarification | J-4c1e061e5b |
| 2026-10-08T14:18:21Z | request_interpreted | J-4c1e061e5b needs_clarification |
| 2026-10-08T14:18:21Z | request_received | |