AI-assisted population-PK analysis — run history
Demonstrator for IncreaseNET Task 7.7 · synthetic data only · generated 2026-10-08T14:34:27Z · tool 0.1.0
Run tree
| Run | Type | Spec (methodology) | Status | OFV | Flags (|Δ| > 20%) | Script hash |
|---|---|---|---|---|---|---|
| R-20261008-134033-5040 | primary | 2-cmt · combined · IIV CL/V2/KA · FOCEi · BLQ M1 | completed | 4372.5187 | — | f4123a0e77a2 |
| └─ R-20261008-134356-4ad9 | sensitivity | 2-cmt · combined · IIV CL/V2/KA · FOCEi · BLQ M3 | completed | 4397.446 | — | 252de1359468 |
| └─ R-20261008-134626-7037 | sensitivityreplay | 2-cmt · combined · IIV CL/V2/KA · FOCEi · BLQ M3 | completed | 4397.2047 | — | 252de1359468 |
| └─ R-20261008-141300-3341 | sensitivity | 2-cmt · combined · IIV CL/V2/KA · FOCEi · BLQ M3 | completed | 4397.2982 | — | fdffd00a137b |
| └─ R-20261008-141415-6b4a | sensitivityreplay | 2-cmt · combined · IIV CL/V2/KA · FOCEi · BLQ M3 | completed | 4397.2982 | — | fdffd00a137b |
Side-by-side comparison
| Parameter | Applicant | 134033-5040 primary BLQ M1 | 134356-4ad9 sensitivity BLQ M3 | 134626-7037 sensitivity · replay BLQ M3 | 141300-3341 sensitivity BLQ M3 | 141415-6b4a sensitivity · replay BLQ M3 |
|---|---|---|---|---|---|---|
| CL/F (L/h) | 4.2 | 4.09 -2.6% | 4.14 -1.4% | 4.14 -1.3% | 4.14 -1.4% | 4.14 -1.4% |
| V2/F (L) | 35 | 35.4 +1.2% | 35.2 +0.6% | 35.2 +0.6% | 35.2 +0.6% | 35.2 +0.6% |
| Q/F (L/h) | 8.1 | 7.96 -1.8% | 7.97 -1.6% | 7.98 -1.5% | 7.97 -1.6% | 7.97 -1.6% |
| V3/F (L) | 120 | 117 -2.1% | 115 -4.5% | 115 -4.4% | 115 -4.4% | 115 -4.4% |
| KA (1/h) | 1.1 | 1.14 +3.7% | 1.13 +3.1% | 1.13 +3.1% | 1.13 +3.1% | 1.13 +3.1% |
| IIV CL (CV%) | 30 | 26.6 -11.4% | 27.5 -8.3% | 27.4 -8.7% | 27.4 -8.8% | 27.4 -8.8% |
| OFV | 4372.5187 | 4397.446 | 4397.2047 | 4397.2982 | 4397.2982 | |
| Observations used | 413 | 420 | 420 | 420 | 420 | |
| Censored (M3) | 0 | 7 | 7 | 7 | 7 | |
| Converged | yes | yes | yes | yes | yes |
Cells show the independent estimate and its relative difference to the applicant's value; highlighted values exceed the tolerance.
Requests rejected or not executed
| Time | Request (pseudonymised) | Outcome | Reasons |
|---|---|---|---|
| 2026-10-08T13:45:16Z | Add a time-varying covariate on CL | out of scope – expert review | unsupported request: Time-varying covariate on CL |
Determinism checks
| Time | Check | Result |
|---|---|---|
| 2026-10-08T13:46:26Z | Re-render script of R-20261008-134356-4ad9 from stored spec | identical script hash 252de1359468ef60 |
| 2026-10-08T13:46:34Z | Re-run R-20261008-134356-4ad9 → R-20261008-134626-7037 | max relative difference 0.0127 (tolerance 1e-06), OFV 4397.446042 vs 4397.204674 |
| 2026-10-08T14:14:15Z | Re-render script of R-20261008-141300-3341 from stored spec | identical script hash fdffd00a137b56c3 |
| 2026-10-08T14:14:30Z | Re-run R-20261008-141300-3341 → R-20261008-141415-6b4a | max relative difference 0 (tolerance 1e-06), OFV 4397.298164 vs 4397.298164 |
Audit log (latest events)
37 events
| Time | Event | Details |
|---|---|---|
| 2026-10-08T14:34:24Z | request_interpreted | J-0388f8e042 needs_clarification |
| 2026-10-08T14:34:20Z | request_received | |
| 2026-10-08T14:14:30Z | determinism_replay | |
| 2026-10-08T14:14:30Z | run_completed | R-20261008-141415-6b4a completed |
| 2026-10-08T14:14:15Z | qc_completed | R-20261008-141415-6b4a |
| 2026-10-08T14:14:15Z | run_started | R-20261008-141415-6b4a |
| 2026-10-08T14:14:15Z | determinism_rerender | R-20261008-141300-3341 |
| 2026-10-08T14:13:14Z | run_completed | R-20261008-141300-3341 completed |
| 2026-10-08T14:13:00Z | qc_completed | R-20261008-141300-3341 |
| 2026-10-08T14:13:00Z | run_started | R-20261008-141300-3341 |
| 2026-10-08T14:13:00Z | spec_confirmed | |
| 2026-10-08T14:11:53Z | spec_proposed | |
| 2026-10-08T14:11:53Z | request_interpreted | J-71710b716b ok |
| 2026-10-08T14:11:50Z | request_received | |
| 2026-10-08T13:46:34Z | determinism_replay | |
| 2026-10-08T13:46:34Z | run_completed | R-20261008-134626-7037 completed |
| 2026-10-08T13:46:26Z | qc_completed | R-20261008-134626-7037 |
| 2026-10-08T13:46:26Z | run_started | R-20261008-134626-7037 |
| 2026-10-08T13:46:26Z | determinism_rerender | R-20261008-134356-4ad9 |
| 2026-10-08T13:45:16Z | request_rejected | |
| 2026-10-08T13:45:16Z | request_interpreted | J-d229f30124 ok |
| 2026-10-08T13:45:14Z | request_received | |
| 2026-10-08T13:44:11Z | run_completed | R-20261008-134356-4ad9 completed |
| 2026-10-08T13:43:56Z | qc_completed | R-20261008-134356-4ad9 |
| 2026-10-08T13:43:56Z | run_started | R-20261008-134356-4ad9 |
| 2026-10-08T13:43:56Z | spec_confirmed | |
| 2026-10-08T13:42:55Z | spec_proposed | |
| 2026-10-08T13:42:55Z | request_interpreted | J-67ed97fd34 ok |
| 2026-10-08T13:42:53Z | request_received | |
| 2026-10-08T13:40:49Z | run_completed | R-20261008-134033-5040 completed |
| 2026-10-08T13:40:33Z | qc_completed | R-20261008-134033-5040 |
| 2026-10-08T13:40:33Z | run_started | R-20261008-134033-5040 |
| 2026-10-08T13:40:33Z | spec_confirmed | |
| 2026-10-08T13:39:15Z | spec_proposed | |
| 2026-10-08T13:39:12Z | clarification | J-b823cbe978 |
| 2026-10-08T13:39:12Z | request_interpreted | J-b823cbe978 needs_clarification |
| 2026-10-08T13:39:07Z | request_received | |